Murray sat stoically with his hands crossed as Superior Court Judge Michael Pastor criticised him for a "horrific violation of trust" in caring for the US pop superstar.
The judge called Murray's actions "money for medicine madness that is simply not acceptable to me".
As he was led away from the Los Angeles court, the defendant blew a kiss to supporters.
Prosecutors pushed for a full four-year jail term as they argued his treatment of Jackson with a powerful anaesthetic ended his life and left his three children without a father.
Murray, 58, was denied probation, despite a request from his lawyers who said it was more appropriate given his lack of a criminal history and the fact he will lose his medical licence.
The "Thriller" singer died of a drug overdose in June 2009, principally from the use of the surgical anaesthetic propofol as a sleeping aid.
That drug had been obtained and administered to Jackson by Murray at the singer's rented home.
The judge added: "Dr Murray created a set of circumstances and became involved in a cycle of horrible medicine.
"The practice of propofol for medicine madness, which violated his sworn obligation, for money, fame prestige and whatever else may have occurred."
Earlier this month, a jury convicted Murray of involuntary manslaughter, or gross negligence, in his treatment of Jackson.
Witnesses testified propofol should not be administered at home and, even if it is, it must be given only with the proper life-monitoring equipment on hand. It was not.
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